GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs8078723 | 1 | rs1042658 | chr17:38173902 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.89 | 0.000117 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | FAM119B | chr12:58166383-58176323:+ | 0.28 | 4.45 | 1.13E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | TSFM | chr12:58176536-58191367:+ | -0.37 | -6.54 | 2.02E-10 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.24 | -4.17 | 3.8E-5 | Multiple sclerosis |
| BLCA | cis | rs6087771 | 1 | rs10439607 | chr20:30258541 | COX4I2 | chr20:30225691-30232800:+ | 0.23 | 4.99 | 9.15E-7 | Subcortical brain region volumes |
| BLCA | cis | rs6087771 | 1 | rs10439608 | chr20:30258814 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.58 | 6.2E-6 | Subcortical brain region volumes |
| BLCA | cis | rs4660306 | 1 | rs1044717 | chr1:45976587 | CCDC163P | chr1:45960581-45965646:- | -0.82 | -16.69 | 2.12E-47 | Homocysteine levels |
| BLCA | cis | rs1577917 | 1 | rs10455158 | chr6:86672825 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -8.75 | 6.72E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs2294008 | 1 | rs1045531 | chr8:143763547 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.79 | 2.43E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs1045531 | chr8:143763547 | PSCA | chr8:143761875-143764142:+ | 0.51 | 15.95 | 2.78E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs1577917 | 1 | rs10455449 | chr6:86592226 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -9.83 | 1.78E-20 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs10455455 | chr6:86670214 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.26 | 1.51E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs10455456 | chr6:86670322 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -8.72 | 8.82E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs2294008 | 1 | rs1045547 | chr8:143763757 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.79 | 2.43E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs1045547 | chr8:143763757 | PSCA | chr8:143761875-143764142:+ | 0.51 | 15.95 | 2.78E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |